Lecture 28. Glucose catabolism

Wednesday 16 November 2016

Stages of glycolysis. Details of glycolytic enzymes, reactions and mechanisms. Aldolase, TIM, GAPDH. Fates of pyruvate.

Reading: VVP4e - Ch.15, pp.472-491.

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Summary

The steps following the aldol cleavage reaction catalyzed by aldolase are typically viewed as a "second stage" of glycolysis involving a series of three-carbon intermediate metabolities. The enzyme triose phosphate isomerase (or TIM) completes the conversion of D-glucose into two three-carbon molecules of glyceraldehyde 3-phosphate (GAP). From that point GAP is converted in five steps to pyruvate. Pyruvate can be considered the end product of glycolysis, and it has a number of possible fates.